Actifed Multi Action Dry Coughs Liquid 10mg/5ml/30mg/5ml/1.25mg/5ml – 100ml

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What Is Actifed Multi-Action Dry Coughs Liquid Used For?
Cold and upper respiratory tract infections often come with a combination of distressing symptoms that can make it difficult to sleep, work, or simply get through the day comfortably. Actifed Multi-Action Dry Coughs Liquid is a pharmacy-only medicine formulated to help relieve three of the most common and disruptive symptoms simultaneously: a dry, irritating cough, a blocked nose, and a runny nose. By addressing all three in a single liquid preparation, it offers a practical and effective option for adults and children aged 6 and over who are looking for broad symptomatic relief during a cold or upper respiratory infection.
The product contains three active ingredients, each targeting a specific symptom. Dextromethorphan hydrobromide at 10mg per 5ml is a well-established cough suppressant that acts centrally on the cough reflex in the brain, helping to reduce the frequency and intensity of a dry, unproductive cough. Unlike cough suppressants that cause significant drowsiness, dextromethorphan at therapeutic doses has a relatively favourable tolerability profile, though some sedation can occur. Pseudoephedrine hydrochloride at 30mg per 5ml is a sympathomimetic decongestant that acts on adrenergic receptors in the nasal mucosa, causing vasoconstriction and reducing swelling of the nasal passages to relieve congestion and improve breathing. Triprolidine hydrochloride at 1.25mg per 5ml is a first-generation antihistamine that helps to relieve the runny nose and sneezing associated with the histamine-mediated component of cold symptoms.
Actifed Multi-Action Dry Coughs Liquid is a clear, pleasant-tasting liquid that is easy to measure and administer, making it a convenient option for those who find tablets difficult to swallow or who prefer a liquid format. It is available in a 100ml bottle providing multiple doses for the typical duration of a cold.
This is a Pharmacy (P) medicine and is only available under the supervision of a pharmacist. It is not suitable for everyone — there are important contraindications and interactions, particularly with monoamine oxidase inhibitors (MAOIs), that must be assessed before purchase. Please speak to a Pearl Chemist Group pharmacist before purchasing this product to ensure it is safe and appropriate for you. You can also browse our full cough, cold and flu range for further options.
How to Use Actifed Multi-Action Dry Coughs Liquid
- Check that this product is suitable for you before use. This is a Pharmacy (P) medicine. Ensure you have been assessed as suitable by a Pearl Chemist Group pharmacist before taking your first dose, particularly regarding MAOI use and cardiovascular conditions.
- Measure your dose accurately. Use a calibrated 5ml medicine measuring spoon or oral dosing syringe. Adults and those aged 12 and over take 10ml per dose. Children aged 6 to 11 take 5ml per dose. Do not use a household teaspoon.
- Take by mouth at the correct intervals. Take one dose every 4 to 6 hours as needed. Do not take doses more frequently than every 4 hours. Do not exceed 4 doses in 24 hours.
- Take with or without food. Actifed Multi-Action Dry Coughs Liquid may be taken with or without food. If stomach upset occurs, taking with food or a glass of water may help.
- Do not take alongside other cold, cough, or decongestant preparations. Check that any other cold or cough products you are using do not contain the same active ingredients — dextromethorphan, pseudoephedrine, or an antihistamine — as doubling up could cause serious side effects.
- Replace the cap securely after every dose. Store the bottle as directed and keep out of reach of children.
Practical tips
- The triprolidine component may cause drowsiness — do not drive or operate machinery after taking this product until you know how it affects you.
- Avoid alcohol whilst taking this product, as it can increase the sedating effects of triprolidine and dextromethorphan significantly.
- If your cough becomes productive (producing phlegm or mucus), changes in character, or is associated with a high fever, difficulty breathing, or chest pain, stop using the product and seek medical advice promptly.
Actifed Multi-Action Dry Coughs Liquid Side Effects
Like all medicines, Actifed Multi-Action Dry Coughs Liquid can cause side effects, although not everybody experiences them. The following are based on the known profiles of the three active ingredients.
Common side effects (may affect more than 1 in 10 people)
- Drowsiness or sedation, primarily from the triprolidine component — do not drive or operate machinery if affected
- Dry mouth, attributed to the anticholinergic effects of triprolidine
- Mild dizziness or light-headedness
Less common side effects (may affect between 1 in 10 and 1 in 100 people)
- Difficulty sleeping (insomnia) or restlessness, particularly from the pseudoephedrine component
- Increased heart rate (palpitations) or awareness of the heartbeat, related to pseudoephedrine
- Increased blood pressure — of particular relevance to those with pre-existing hypertension
- Headache
- Nausea or stomach discomfort
- Difficulty passing urine, particularly in men with an enlarged prostate, related to the anticholinergic effect of triprolidine
- Blurred vision, related to the anticholinergic effect of triprolidine
Rare side effects (may affect fewer than 1 in 100 people)
- Allergic skin reaction, including rash or itching
- Confusion or disorientation, particularly in elderly individuals
- Hallucinations or unusual behaviour, particularly with dextromethorphan in susceptible individuals or at excessive doses
- Serious cardiovascular effects (very rare at recommended doses): irregular heartbeat or significant rise in blood pressure
Stop using and seek urgent medical help if you experience:
- A sudden or severe headache, particularly if accompanied by a rapid rise in blood pressure, stiff neck, palpitations, or chest pain — these may indicate a serious reaction, particularly in those with unrecognised cardiovascular conditions or MAOI use
- Difficulty breathing, significant chest tightness, or wheezing
- Signs of a serious allergic reaction including facial swelling, throat swelling, or a widespread rash — call 999 immediately
- Hallucinations, extreme agitation, or confusion
- Any symptom that concerns you significantly or that you believe may be related to this product
Report any unexpected reaction via the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk or speak to your Pearl Chemist Group pharmacist.
How to Store Actifed Multi-Action Dry Coughs Liquid
- Temperature: Store below 25°C. Keep away from direct sunlight and sources of heat.
- Original packaging: Keep in the original bottle with the cap firmly replaced after every use.
- Do not refrigerate.
- Children: Keep out of the sight and reach of children at all times. This product contains active ingredients — particularly pseudoephedrine — that can be harmful if taken in larger quantities than directed.
- Expiry: Do not use after the expiry date printed on the bottle and outer packaging.
- Disposal: Do not dispose of via wastewater or household waste. Return unused or out-of-date medicine to your Pearl Chemist Group pharmacy for safe disposal.
Who Is Actifed Multi-Action Dry Coughs Liquid Suitable For?
Actifed Multi-Action Dry Coughs Liquid is a Pharmacy (P) medicine suitable for adults and children aged 6 and over who experience a dry, irritating cough, nasal congestion, and runny nose as part of a cold or upper respiratory tract infection, and who have been assessed as suitable by a pharmacist.
Suitable for:
- Adults aged 18 and over with a dry cough, blocked nose, and runny nose associated with a cold or upper respiratory infection
- Children aged 6 to 11 years at the lower paediatric dose, subject to pharmacist guidance and adult supervision
- Young people aged 12 and over at the adult dose, under appropriate supervision
- Those who prefer or require a multi-symptom liquid cold remedy
Not suitable for — do not use if you:
- Are currently taking or have taken a monoamine oxidase inhibitor (MAOI) antidepressant within the last 14 days — this is a serious, potentially life-threatening contraindication
- Have severe or uncontrolled high blood pressure (hypertension)
- Have severe coronary artery disease or a serious heart condition
- Have an overactive thyroid gland (hyperthyroidism)
- Have a phaeochromocytoma (a rare adrenal gland tumour)
- Are under 6 years of age
- Have a known allergy or hypersensitivity to dextromethorphan, pseudoephedrine, triprolidine, or any other ingredient
- Are pregnant or breastfeeding
Seek pharmacist advice before use if you:
- Have high blood pressure that is controlled with medication
- Have diabetes, glaucoma, an enlarged prostate, liver disease, or kidney impairment
- Are taking any other medicines, including prescribed, over-the-counter, or herbal preparations
- Are elderly, as the risk of side effects from pseudoephedrine and triprolidine is increased
- Have a persistent cough, a cough that produces phlegm, or a cough associated with asthma or chronic respiratory conditions — this product is only appropriate for dry, unproductive coughs
This product must be purchased in person from Pearl Chemist Group under the supervision of a pharmacist. Our pharmacists will assess suitability before every sale.
Active Ingredients in Actifed Multi-Action Dry Coughs Liquid
| Ingredient | Strength per 5ml | Role |
|---|---|---|
| Dextromethorphan hydrobromide | 10mg | A centrally acting cough suppressant. Dextromethorphan acts on the cough centre in the brain to help reduce the frequency and intensity of a dry, unproductive cough. It does not treat the underlying cause of the cough but helps to relieve the discomfort and disruption caused by persistent dry coughing, particularly at night. It is one of the most widely used and studied cough suppressants available without prescription in the UK. |
| Pseudoephedrine hydrochloride | 30mg | A sympathomimetic nasal decongestant. Pseudoephedrine acts on adrenergic receptors in the blood vessels of the nasal mucosa, causing vasoconstriction and reducing the swelling and congestion that blocks the nasal passages during a cold. This helps to relieve the sensation of a blocked nose and improve nasal airflow. It has a longer duration of action than some topical nasal decongestants and is taken orally. |
| Triprolidine hydrochloride | 1.25mg | A first-generation antihistamine. Triprolidine blocks histamine H1 receptors, helping to relieve the runny nose, sneezing, and watery eyes that are associated with the histamine response triggered during colds and upper respiratory infections. As a first-generation antihistamine, it may cause some drowsiness, which can be a useful secondary benefit for those experiencing disturbed sleep due to cold symptoms. |
Actifed Multi-Action Dry Coughs Liquid Dosage — How Much to Take
Adults and young people aged 12 and over
- Dose: 10ml (2 x 5ml spoonfuls) per dose.
- Frequency: Every 4 to 6 hours as needed.
- Maximum daily dose: 4 doses in any 24-hour period (maximum 40ml per day).
Children aged 6 to 11 years
- Dose: 5ml per dose.
- Frequency: Every 4 to 6 hours as needed.
- Maximum daily dose: 4 doses in 24 hours (maximum 20ml per day).
- Always administer under adult supervision.
Children under 6 years
Not recommended.
Elderly patients
Use with particular caution in elderly patients. Pseudoephedrine can raise blood pressure and may affect the heart rate. Triprolidine may cause increased sedation and confusion in older people. Seek pharmacist or GP advice before use in elderly individuals, particularly those with cardiovascular conditions or who are taking multiple medicines.
Important dosage notes
- Measure doses accurately using a 5ml medicine spoon or oral dosing syringe. Do not use a household teaspoon.
- Do not exceed 4 doses in any 24-hour period.
- Do not use for more than 5 to 7 days without seeking pharmacist or GP advice.
- Do not use alongside other products containing dextromethorphan, pseudoephedrine, antihistamines, or decongestants, as this could result in exceeding the safe dose of one or more active ingredients.
Precautions When Using Actifed Multi-Action Dry Coughs Liquid
Before you use this product
- This product must only be purchased under pharmacist supervision. Confirm with a Pearl Chemist Group pharmacist that it is safe and appropriate for you before taking any dose.
- Check the expiry date on the bottle and outer packaging before use.
- Confirm you are not taking any MAOI medicine and have not done so in the last 14 days — this is a critical safety check.
- Review all drug interactions with your pharmacist if you take any regular prescribed or over-the-counter medicines.
- Do not use if you are pregnant or breastfeeding.
- Confirm that your cough is dry and unproductive — this product is not appropriate for a chesty or productive cough.
During use
- Measure doses accurately with a calibrated 5ml spoon or oral dosing syringe.
- Do not take more than 4 doses in 24 hours.
- Do not take alongside any other product containing dextromethorphan, pseudoephedrine, a decongestant, or an antihistamine.
- Avoid alcohol completely during treatment.
- Do not drive or operate machinery until you know how this product affects you, particularly in terms of drowsiness.
- Monitor children aged 6 to 11 closely and administer only the correct paediatric dose under adult supervision.
Duration of use
- Do not use for more than 5 to 7 days without seeking pharmacist or GP advice.
- If your cough or cold symptoms are not improving after this period, or if they are worsening, consult your GP.
When to seek urgent medical advice
- Your cough becomes productive, producing phlegm or blood-stained mucus.
- You develop a high fever, chest pain, difficulty breathing, or wheezing.
- You experience a sudden or severe headache, palpitations, or a rapid rise in blood pressure after taking the product.
- A child taking this product develops unusual behaviour, severe drowsiness, or breathing difficulties.
- You have any concern about your response to this product.
Our Pearl Chemist Group pharmacists are available for advice at every stage of your treatment and can advise on when a GP referral is appropriate.
Full Ingredients in Actifed Multi-Action Dry Coughs Liquid
Active ingredients per 5ml dose: dextromethorphan hydrobromide 10mg, pseudoephedrine hydrochloride 30mg, triprolidine hydrochloride 1.25mg.
Excipients (inactive ingredients)
- Sucrose — sweetening agent providing palatability; people with diabetes should note that each dose contains sugar and should take this into account when monitoring carbohydrate intake
- Ethanol — used as a solvent in the formulation; those who avoid alcohol for religious, medical, or personal reasons should be aware of its presence, although the quantity per dose is small
- Citric acid — acidulant that contributes to flavour balance and helps maintain formulation stability
- Sodium citrate — buffering agent that helps maintain the correct pH of the liquid and works alongside citric acid to provide flavour balance
- Menthol — flavouring agent that contributes a cool, refreshing taste and mild soothing sensation
- Caramel — colouring agent that gives the liquid its characteristic amber-brown colour
- Purified water — aqueous base of the formulation
This product contains sucrose (relevant for those with diabetes or those monitoring sugar intake) and ethanol (relevant for those avoiding alcohol). If you have any concerns about these excipients in relation to your health or beliefs, consult a Pearl Chemist Group pharmacist before use.
Last reviewed: May 2026.
Always read the patient information leaflet before use. A copy is included in the pack. For advice, speak to a Pearl Chemist pharmacist or call +44 (0)20 8672 2157.
What Is Actifed Multi-Action Dry Coughs Liquid Used For?
Cold and upper respiratory tract infections often come with a combination of distressing symptoms that can make it difficult to sleep, work, or simply get through the day comfortably. Actifed Multi-Action Dry Coughs Liquid is a pharmacy-only medicine formulated to help relieve three of the most common and disruptive symptoms simultaneously: a dry, irritating cough, a blocked nose, and a runny nose. By addressing all three in a single liquid preparation, it offers a practical and effective option for adults and children aged 6 and over who are looking for broad symptomatic relief during a cold or upper respiratory infection.
The product contains three active ingredients, each targeting a specific symptom. Dextromethorphan hydrobromide at 10mg per 5ml is a well-established cough suppressant that acts centrally on the cough reflex in the brain, helping to reduce the frequency and intensity of a dry, unproductive cough. Unlike cough suppressants that cause significant drowsiness, dextromethorphan at therapeutic doses has a relatively favourable tolerability profile, though some sedation can occur. Pseudoephedrine hydrochloride at 30mg per 5ml is a sympathomimetic decongestant that acts on adrenergic receptors in the nasal mucosa, causing vasoconstriction and reducing swelling of the nasal passages to relieve congestion and improve breathing. Triprolidine hydrochloride at 1.25mg per 5ml is a first-generation antihistamine that helps to relieve the runny nose and sneezing associated with the histamine-mediated component of cold symptoms.
Actifed Multi-Action Dry Coughs Liquid is a clear, pleasant-tasting liquid that is easy to measure and administer, making it a convenient option for those who find tablets difficult to swallow or who prefer a liquid format. It is available in a 100ml bottle providing multiple doses for the typical duration of a cold.
This is a Pharmacy (P) medicine and is only available under the supervision of a pharmacist. It is not suitable for everyone — there are important contraindications and interactions, particularly with monoamine oxidase inhibitors (MAOIs), that must be assessed before purchase. Please speak to a Pearl Chemist Group pharmacist before purchasing this product to ensure it is safe and appropriate for you. You can also browse our full cough, cold and flu range for further options.
How to Use Actifed Multi-Action Dry Coughs Liquid
- Check that this product is suitable for you before use. This is a Pharmacy (P) medicine. Ensure you have been assessed as suitable by a Pearl Chemist Group pharmacist before taking your first dose, particularly regarding MAOI use and cardiovascular conditions.
- Measure your dose accurately. Use a calibrated 5ml medicine measuring spoon or oral dosing syringe. Adults and those aged 12 and over take 10ml per dose. Children aged 6 to 11 take 5ml per dose. Do not use a household teaspoon.
- Take by mouth at the correct intervals. Take one dose every 4 to 6 hours as needed. Do not take doses more frequently than every 4 hours. Do not exceed 4 doses in 24 hours.
- Take with or without food. Actifed Multi-Action Dry Coughs Liquid may be taken with or without food. If stomach upset occurs, taking with food or a glass of water may help.
- Do not take alongside other cold, cough, or decongestant preparations. Check that any other cold or cough products you are using do not contain the same active ingredients — dextromethorphan, pseudoephedrine, or an antihistamine — as doubling up could cause serious side effects.
- Replace the cap securely after every dose. Store the bottle as directed and keep out of reach of children.
Practical tips
- The triprolidine component may cause drowsiness — do not drive or operate machinery after taking this product until you know how it affects you.
- Avoid alcohol whilst taking this product, as it can increase the sedating effects of triprolidine and dextromethorphan significantly.
- If your cough becomes productive (producing phlegm or mucus), changes in character, or is associated with a high fever, difficulty breathing, or chest pain, stop using the product and seek medical advice promptly.
Actifed Multi-Action Dry Coughs Liquid Side Effects
Like all medicines, Actifed Multi-Action Dry Coughs Liquid can cause side effects, although not everybody experiences them. The following are based on the known profiles of the three active ingredients.
Common side effects (may affect more than 1 in 10 people)
- Drowsiness or sedation, primarily from the triprolidine component — do not drive or operate machinery if affected
- Dry mouth, attributed to the anticholinergic effects of triprolidine
- Mild dizziness or light-headedness
Less common side effects (may affect between 1 in 10 and 1 in 100 people)
- Difficulty sleeping (insomnia) or restlessness, particularly from the pseudoephedrine component
- Increased heart rate (palpitations) or awareness of the heartbeat, related to pseudoephedrine
- Increased blood pressure — of particular relevance to those with pre-existing hypertension
- Headache
- Nausea or stomach discomfort
- Difficulty passing urine, particularly in men with an enlarged prostate, related to the anticholinergic effect of triprolidine
- Blurred vision, related to the anticholinergic effect of triprolidine
Rare side effects (may affect fewer than 1 in 100 people)
- Allergic skin reaction, including rash or itching
- Confusion or disorientation, particularly in elderly individuals
- Hallucinations or unusual behaviour, particularly with dextromethorphan in susceptible individuals or at excessive doses
- Serious cardiovascular effects (very rare at recommended doses): irregular heartbeat or significant rise in blood pressure
Stop using and seek urgent medical help if you experience:
- A sudden or severe headache, particularly if accompanied by a rapid rise in blood pressure, stiff neck, palpitations, or chest pain — these may indicate a serious reaction, particularly in those with unrecognised cardiovascular conditions or MAOI use
- Difficulty breathing, significant chest tightness, or wheezing
- Signs of a serious allergic reaction including facial swelling, throat swelling, or a widespread rash — call 999 immediately
- Hallucinations, extreme agitation, or confusion
- Any symptom that concerns you significantly or that you believe may be related to this product
Report any unexpected reaction via the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk or speak to your Pearl Chemist Group pharmacist.
How to Store Actifed Multi-Action Dry Coughs Liquid
- Temperature: Store below 25°C. Keep away from direct sunlight and sources of heat.
- Original packaging: Keep in the original bottle with the cap firmly replaced after every use.
- Do not refrigerate.
- Children: Keep out of the sight and reach of children at all times. This product contains active ingredients — particularly pseudoephedrine — that can be harmful if taken in larger quantities than directed.
- Expiry: Do not use after the expiry date printed on the bottle and outer packaging.
- Disposal: Do not dispose of via wastewater or household waste. Return unused or out-of-date medicine to your Pearl Chemist Group pharmacy for safe disposal.
Who Is Actifed Multi-Action Dry Coughs Liquid Suitable For?
Actifed Multi-Action Dry Coughs Liquid is a Pharmacy (P) medicine suitable for adults and children aged 6 and over who experience a dry, irritating cough, nasal congestion, and runny nose as part of a cold or upper respiratory tract infection, and who have been assessed as suitable by a pharmacist.
Suitable for:
- Adults aged 18 and over with a dry cough, blocked nose, and runny nose associated with a cold or upper respiratory infection
- Children aged 6 to 11 years at the lower paediatric dose, subject to pharmacist guidance and adult supervision
- Young people aged 12 and over at the adult dose, under appropriate supervision
- Those who prefer or require a multi-symptom liquid cold remedy
Not suitable for — do not use if you:
- Are currently taking or have taken a monoamine oxidase inhibitor (MAOI) antidepressant within the last 14 days — this is a serious, potentially life-threatening contraindication
- Have severe or uncontrolled high blood pressure (hypertension)
- Have severe coronary artery disease or a serious heart condition
- Have an overactive thyroid gland (hyperthyroidism)
- Have a phaeochromocytoma (a rare adrenal gland tumour)
- Are under 6 years of age
- Have a known allergy or hypersensitivity to dextromethorphan, pseudoephedrine, triprolidine, or any other ingredient
- Are pregnant or breastfeeding
Seek pharmacist advice before use if you:
- Have high blood pressure that is controlled with medication
- Have diabetes, glaucoma, an enlarged prostate, liver disease, or kidney impairment
- Are taking any other medicines, including prescribed, over-the-counter, or herbal preparations
- Are elderly, as the risk of side effects from pseudoephedrine and triprolidine is increased
- Have a persistent cough, a cough that produces phlegm, or a cough associated with asthma or chronic respiratory conditions — this product is only appropriate for dry, unproductive coughs
This product must be purchased in person from Pearl Chemist Group under the supervision of a pharmacist. Our pharmacists will assess suitability before every sale.
Active Ingredients in Actifed Multi-Action Dry Coughs Liquid
| Ingredient | Strength per 5ml | Role |
|---|---|---|
| Dextromethorphan hydrobromide | 10mg | A centrally acting cough suppressant. Dextromethorphan acts on the cough centre in the brain to help reduce the frequency and intensity of a dry, unproductive cough. It does not treat the underlying cause of the cough but helps to relieve the discomfort and disruption caused by persistent dry coughing, particularly at night. It is one of the most widely used and studied cough suppressants available without prescription in the UK. |
| Pseudoephedrine hydrochloride | 30mg | A sympathomimetic nasal decongestant. Pseudoephedrine acts on adrenergic receptors in the blood vessels of the nasal mucosa, causing vasoconstriction and reducing the swelling and congestion that blocks the nasal passages during a cold. This helps to relieve the sensation of a blocked nose and improve nasal airflow. It has a longer duration of action than some topical nasal decongestants and is taken orally. |
| Triprolidine hydrochloride | 1.25mg | A first-generation antihistamine. Triprolidine blocks histamine H1 receptors, helping to relieve the runny nose, sneezing, and watery eyes that are associated with the histamine response triggered during colds and upper respiratory infections. As a first-generation antihistamine, it may cause some drowsiness, which can be a useful secondary benefit for those experiencing disturbed sleep due to cold symptoms. |
Actifed Multi-Action Dry Coughs Liquid Dosage — How Much to Take
Adults and young people aged 12 and over
- Dose: 10ml (2 x 5ml spoonfuls) per dose.
- Frequency: Every 4 to 6 hours as needed.
- Maximum daily dose: 4 doses in any 24-hour period (maximum 40ml per day).
Children aged 6 to 11 years
- Dose: 5ml per dose.
- Frequency: Every 4 to 6 hours as needed.
- Maximum daily dose: 4 doses in 24 hours (maximum 20ml per day).
- Always administer under adult supervision.
Children under 6 years
Not recommended.
Elderly patients
Use with particular caution in elderly patients. Pseudoephedrine can raise blood pressure and may affect the heart rate. Triprolidine may cause increased sedation and confusion in older people. Seek pharmacist or GP advice before use in elderly individuals, particularly those with cardiovascular conditions or who are taking multiple medicines.
Important dosage notes
- Measure doses accurately using a 5ml medicine spoon or oral dosing syringe. Do not use a household teaspoon.
- Do not exceed 4 doses in any 24-hour period.
- Do not use for more than 5 to 7 days without seeking pharmacist or GP advice.
- Do not use alongside other products containing dextromethorphan, pseudoephedrine, antihistamines, or decongestants, as this could result in exceeding the safe dose of one or more active ingredients.
Precautions When Using Actifed Multi-Action Dry Coughs Liquid
Before you use this product
- This product must only be purchased under pharmacist supervision. Confirm with a Pearl Chemist Group pharmacist that it is safe and appropriate for you before taking any dose.
- Check the expiry date on the bottle and outer packaging before use.
- Confirm you are not taking any MAOI medicine and have not done so in the last 14 days — this is a critical safety check.
- Review all drug interactions with your pharmacist if you take any regular prescribed or over-the-counter medicines.
- Do not use if you are pregnant or breastfeeding.
- Confirm that your cough is dry and unproductive — this product is not appropriate for a chesty or productive cough.
During use
- Measure doses accurately with a calibrated 5ml spoon or oral dosing syringe.
- Do not take more than 4 doses in 24 hours.
- Do not take alongside any other product containing dextromethorphan, pseudoephedrine, a decongestant, or an antihistamine.
- Avoid alcohol completely during treatment.
- Do not drive or operate machinery until you know how this product affects you, particularly in terms of drowsiness.
- Monitor children aged 6 to 11 closely and administer only the correct paediatric dose under adult supervision.
Duration of use
- Do not use for more than 5 to 7 days without seeking pharmacist or GP advice.
- If your cough or cold symptoms are not improving after this period, or if they are worsening, consult your GP.
When to seek urgent medical advice
- Your cough becomes productive, producing phlegm or blood-stained mucus.
- You develop a high fever, chest pain, difficulty breathing, or wheezing.
- You experience a sudden or severe headache, palpitations, or a rapid rise in blood pressure after taking the product.
- A child taking this product develops unusual behaviour, severe drowsiness, or breathing difficulties.
- You have any concern about your response to this product.
Our Pearl Chemist Group pharmacists are available for advice at every stage of your treatment and can advise on when a GP referral is appropriate.
Full Ingredients in Actifed Multi-Action Dry Coughs Liquid
Active ingredients per 5ml dose: dextromethorphan hydrobromide 10mg, pseudoephedrine hydrochloride 30mg, triprolidine hydrochloride 1.25mg.
Excipients (inactive ingredients)
- Sucrose — sweetening agent providing palatability; people with diabetes should note that each dose contains sugar and should take this into account when monitoring carbohydrate intake
- Ethanol — used as a solvent in the formulation; those who avoid alcohol for religious, medical, or personal reasons should be aware of its presence, although the quantity per dose is small
- Citric acid — acidulant that contributes to flavour balance and helps maintain formulation stability
- Sodium citrate — buffering agent that helps maintain the correct pH of the liquid and works alongside citric acid to provide flavour balance
- Menthol — flavouring agent that contributes a cool, refreshing taste and mild soothing sensation
- Caramel — colouring agent that gives the liquid its characteristic amber-brown colour
- Purified water — aqueous base of the formulation
This product contains sucrose (relevant for those with diabetes or those monitoring sugar intake) and ethanol (relevant for those avoiding alcohol). If you have any concerns about these excipients in relation to your health or beliefs, consult a Pearl Chemist Group pharmacist before use.
Last reviewed: May 2026.
Always read the patient information leaflet before use. A copy is included in the pack. For advice, speak to a Pearl Chemist pharmacist or call +44 (0)20 8672 2157.
FAQs
Actifed Multi-Action Dry Coughs Liquid is classified as a Pharmacy (P) medicine because it contains pseudoephedrine, a nasal decongestant that can interact seriously with certain medicines, most notably monoamine oxidase inhibitors (MAOIs), and that requires careful assessment in individuals with high blood pressure, heart disease, hyperthyroidism, and other conditions. A pharmacist must assess suitability before every sale to ensure it is safe for the person purchasing it. This pharmacist supervision is a legal requirement, not simply a precaution, and is in place to protect your safety.
MAOIs interact seriously with both pseudoephedrine and dextromethorphan. Combining pseudoephedrine with an MAOI can cause a hypertensive crisis — a sudden, severe rise in blood pressure that can be life-threatening. Combining dextromethorphan with an MAOI can cause serotonin syndrome, a potentially dangerous condition characterised by agitation, high temperature, rapid heart rate, and in severe cases, seizures or organ failure. MAOIs remain active in the body for up to 14 days after the last dose, so a full two-week washout period is required before this product can be used safely. Always tell your pharmacist what medicines you are taking before purchasing Actifed.
Pseudoephedrine can raise blood pressure and is contraindicated in severe or uncontrolled hypertension. If your blood pressure is well controlled with medication, you may be able to use this product under pharmacist guidance, but this must be assessed on an individual basis. Speak to your Pearl Chemist Group pharmacist or your GP before taking this product if you have any form of high blood pressure or cardiovascular condition. There may be more suitable alternatives available that do not contain a decongestant.
No. Actifed Multi-Action Dry Coughs Liquid contains dextromethorphan, a cough suppressant. Cough suppressants are only appropriate for dry, unproductive coughs — they should not be used for a chesty or productive cough where the body is using the cough reflex to clear mucus from the airways. Suppressing a productive cough can cause mucus to accumulate and potentially worsen a chest infection. If your cough is productive, speak to a pharmacist about a suitable alternative preparation.
Yes, drowsiness is a common side effect, primarily due to the triprolidine antihistamine component. You should not drive or operate machinery after taking this product until you are confident it is not impairing your ability to do so safely. Alcohol significantly increases the sedating effect and must be avoided during treatment. For some people, particularly those taking the product at night, the mild sedative effect may actually be helpful in managing symptoms that disrupt sleep.
It is suitable for children aged 6 and over at the lower paediatric dose of 5ml per dose, under adult supervision and following pharmacist guidance. It is not recommended for children under 6 years of age. If you are considering this product for a child, please speak to a Pearl Chemist Group pharmacist first, who can confirm suitability, advise on the correct dose, and check for any contraindications specific to the child's health history or any other medicines they may be taking.
In general, Actifed Multi-Action Dry Coughs Liquid does not interact directly with paracetamol or ibuprofen. However, be cautious about using any combination cold product alongside Actifed, as some all-in-one cold and flu remedies already contain a decongestant or antihistamine and combining them could result in excessive doses of pseudoephedrine or triprolidine. Always check the ingredients of any other cold or cough preparation before using it alongside Actifed, and ask your Pearl Chemist Group pharmacist if you are unsure.
Do not use Actifed Multi-Action Dry Coughs Liquid for more than 5 to 7 days without seeking pharmacist or GP advice. If your symptoms are not improving or are worsening during this time — particularly if your cough becomes productive, you develop a high fever, chest pain, or difficulty breathing — stop using the product and seek medical assessment promptly. Cold symptoms that persist beyond 7 to 10 days may sometimes indicate a secondary bacterial infection such as sinusitis or a chest infection, which requires appropriate medical management.