Algesal Local Analgesic Cream – 50g

Algesal Cream contains diethylamine salicylate at 10% w/w, a member of the salicylate class of anti-inflammatory compounds. When massaged into the skin over a painful muscle or joint, it is absorbed through the skin and reaches the underlying tissues, where it inhibits the production of prostaglandins — the inflammatory mediators that drive pain, swelling, and tenderness. By reducing local prostaglandin levels, it helps to relieve pain and inflammation at the site of application without the higher systemic exposure associated with oral anti-inflammatory medicines.

No. Algesal Cream contains diethylamine salicylate, which belongs to the same salicylate family as aspirin. If you have a known allergy to aspirin or other salicylate-containing medicines, you must not use this cream as a cross-reaction is possible. Please speak to a Pearl Chemist Group pharmacist who can recommend a suitable alternative topical analgesic that does not contain salicylates.

Salicylates applied topically can theoretically enhance the anticoagulant effect of warfarin, particularly if used on large areas of skin or over a prolonged period. If you take warfarin or any other anticoagulant medicine, consult your pharmacist or GP before using Algesal Cream. They can advise on whether it is safe for you to use and at what frequency, and whether any monitoring of your INR would be appropriate.

Most people begin to notice some improvement in pain and discomfort within the first few days of regular twice to three times daily application. Anti-inflammatory topical creams generally require consistent use over several days to achieve their full effect. Do not use for more than 7 days without consulting your pharmacist or GP. If your symptoms have not improved after a week of regular use, a medical assessment is recommended to identify the underlying cause of your pain.

Do not apply Algesal Cream under an occlusive (airtight) dressing or tight bandage. Occlusive coverings significantly increase the absorption of topically applied salicylate through the skin, which can raise systemic levels beyond those intended and increase the risk of side effects. You may apply a loose, non-occlusive dressing if required, but allow the cream to absorb fully into the skin before applying any covering.

Algesal Cream should not be used in the third trimester of pregnancy, as salicylates are associated with adverse effects on the developing baby and on labour at this stage of pregnancy. Use in the first or second trimester should only be under pharmacist or GP guidance. If you are pregnant and experiencing muscular or joint pain, consult your midwife, GP, or pharmacist for appropriate and safe pain relief options for your stage of pregnancy.

Both the 50g and 100g Algesal tubes contain exactly the same formulation — diethylamine salicylate 10% w/w in the same cream base. The only difference is the pack size. The 100g tube is an economy option offering better value for those who use the cream regularly for ongoing muscular or rheumatic conditions. The same clinical guidance, dosage, and precautions apply to both sizes.

Yes. Algesal Cream is appropriate for use on soft tissue sports injuries such as muscle strains, ligament sprains, and generalised muscle soreness from overexertion. In the initial 48 to 72 hours after a soft tissue injury, it is generally recommended to combine topical treatment with the RICE approach — Rest, Ice, Compression, and Elevation — to manage swelling and pain effectively. If the injury involves significant swelling, deformity, inability to bear weight, or severe pain, seek medical assessment rather than self-treating, as these may indicate a more serious injury requiring professional management.