Alka-Seltzer XS Tablets 324mg/965mg/1625mg – 20 Tablets

£6.89
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FAQs

What makes Alka-Seltzer XS stronger than the Original formula?
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Alka-Seltzer XS contains three active ingredients — aspirin, paracetamol, and caffeine — whereas Alka-Seltzer Original contains only aspirin (plus the antacid buffer). The combination of two analgesics with complementary mechanisms of action provides greater pain relief than either alone at these doses, and the caffeine further enhances their effectiveness as a recognised analgesic adjuvant. Alka-Seltzer XS is therefore more appropriate for more intense or stubborn pain where standard single-ingredient relief has proved insufficient.

Why is the paracetamol warning so important for Alka-Seltzer XS?
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Paracetamol is found in a very large number of over-the-counter and prescribed medicines — cold and flu remedies, combination pain relief tablets, and many others. Taking Alka-Seltzer XS at the same time as any other product containing paracetamol can easily lead to a total daily paracetamol dose that causes serious and irreversible liver damage. This damage can develop silently, without obvious symptoms, in the first 24 hours. If you are in any doubt about whether another medicine you are taking contains paracetamol, ask your Pearl Chemist Group pharmacist before using Alka-Seltzer XS.

Is the caffeine in Alka-Seltzer XS enough to cause side effects?
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The caffeine content per tablet in Alka-Seltzer XS is relatively low — approximately 40mg per tablet — broadly comparable to a small cup of tea. Most people tolerate this without difficulty. However, if you are particularly sensitive to caffeine, are trying to limit your caffeine intake, or are taking the tablets late in the evening, the caffeine content may contribute to mild restlessness or difficulty sleeping. Those with conditions aggravated by caffeine should consult their pharmacist before use.

Can I take Alka-Seltzer XS for a hangover?
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Alka-Seltzer XS is specifically associated with hangover relief in its marketing heritage, and its combination of aspirin for headache, an antacid for stomach discomfort, and caffeine for alertness does address several hangover symptoms. However, it is important to note that alcohol increases the risk of gastrointestinal irritation from aspirin and the risk of liver stress from paracetamol. If you have consumed a substantial amount of alcohol, allow time for the alcohol to clear your system and drink plenty of water before using Alka-Seltzer XS. Do not take alongside other paracetamol products.

Can I use Alka-Seltzer XS if I am on warfarin?
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No, not without specific medical advice. Aspirin significantly enhances the anticoagulant effect of warfarin and substantially increases the risk of serious bleeding. If you take warfarin or any other anticoagulant, do not use Alka-Seltzer XS or any aspirin-containing product without first consulting your GP or pharmacist. There are aspirin-free analgesic options available that do not carry this interaction risk.

Why must Alka-Seltzer XS not be given to those under 16?
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Alka-Seltzer XS contains aspirin, which must never be given to children and young people under 16 years of age due to the risk of Reye's syndrome — a rare but potentially fatal condition affecting the brain and liver that has been associated with aspirin use in this age group. For pain and fever relief in those under 16, paracetamol-based or ibuprofen-based products (where age-appropriate) are safe and effective alternatives.