Allerief Antihistamine Solution

Trusted by
50,000+ patients
Free Delivery on
Over £30
UK Registered
Pharmacy
What Is Allerief Antihistamine Solution Used For?
Allergic reactions can range from the mildly inconvenient to the significantly distressing, and having an effective antihistamine readily available is an important part of managing both everyday allergic conditions and unexpected allergic responses. Allerief Antihistamine Solution is a liquid antihistamine preparation containing chlorphenamine maleate at 2mg per 5ml, providing a versatile and easy-to-administer treatment for a wide range of allergic conditions across all appropriate age groups, from young children through to adults. The liquid format is particularly valuable for those who have difficulty swallowing tablets and for children, where accurate weight- and age-based dosing in a measured liquid form is more practical and reliable.
Chlorphenamine maleate is a first-generation antihistamine that works by competitively blocking histamine H1 receptors throughout the body, preventing histamine from binding and triggering the cascade of symptoms associated with allergic reactions. Allerief Antihistamine Solution is indicated for the symptomatic relief of allergic conditions including hayfever and seasonal allergic rhinitis, perennial allergic rhinitis, urticaria and allergic skin reactions, insect bites and stings, food allergy reactions causing itching and rash, and other drug reactions producing similar symptoms. It can be used to relieve sneezing, runny nose, nasal congestion, itchy and watery eyes, itchy skin, rash, and urticaria wheals associated with these conditions.
As a first-generation antihistamine, chlorphenamine crosses the blood-brain barrier more readily than second-generation antihistamines such as cetirizine or loratadine, and this results in a significant tendency to cause drowsiness in most users. This sedating property is sometimes useful — it can help children or adults who are experiencing disturbed sleep due to allergy symptoms to rest more comfortably overnight. However, it also means that Allerief Antihistamine Solution must not be used by anyone who needs to drive or operate machinery following administration, and alcohol must be avoided during treatment as it significantly magnifies the sedating effect.
Allerief Antihistamine Solution is suitable for adults and children from 2 years of age at age-appropriate doses. It must not be used in children under 2 without medical advice and must not be taken within 14 days of stopping an MAOI medicine. If you are managing a severe allergic reaction or anaphylaxis, seek emergency help immediately rather than relying on antihistamine treatment alone. For guidance on appropriate allergy management, speak to a Pearl Chemist Group pharmacist, or browse our full allergy treatment range.
How to Use Allerief Antihistamine Solution
- Shake the bottle if required. Check the label for instructions. Shake well before use if indicated to ensure even distribution of the active ingredient throughout the solution.
- Measure the correct dose accurately. Use the measuring device provided with the product or a calibrated 5ml oral syringe. Measure the correct volume for the age and weight of the person being treated. Do not use a household teaspoon, which may not hold exactly 5ml.
- Administer the measured dose. Give the measured dose by mouth. The solution may be swallowed directly or, for young children, measured into a small amount of water or squash if the child finds the taste difficult to accept. Do not mix with large volumes of liquid, as it is then difficult to ensure the full dose is consumed.
- Repeat as needed at the correct interval. A further dose may be given every 4 to 6 hours as needed, up to the stated maximum number of doses in 24 hours.
- Replace the cap securely after every use. Store the bottle as directed and keep out of reach of children.
Important reminders
- The sedating effect typically begins within 30 to 60 minutes of a dose. Do not allow the person taking the medicine to drive or operate machinery after administration.
- Avoid giving alcohol to anyone taking this solution.
- For children's doses, always measure carefully — the doses for 2 to 5 year olds (2.5ml) and 6 to 11 year olds (5ml) are quite small and must be measured precisely.
Allerief Antihistamine Solution Side Effects
Chlorphenamine maleate is a first-generation antihistamine with a well-known profile of sedating and anticholinergic side effects. These are more pronounced than with second-generation antihistamines such as cetirizine.
Common side effects (may affect more than 1 in 10 people)
- Drowsiness and sedation — this is the most common and expected effect; can range from mild to significant depending on the individual and the dose
- Dry mouth — due to anticholinergic activity
- Dizziness or light-headedness
Less common side effects (may affect between 1 in 10 and 1 in 100 people)
- Difficulty passing urine, particularly in men with an enlarged prostate
- Blurred vision
- Constipation
- Headache
- Nausea or stomach discomfort
- Palpitations or irregular heartbeat in some individuals
Rare side effects (may affect fewer than 1 in 100 people)
- Paradoxical excitation, particularly in children — manifesting as restlessness, agitation, hyperactivity, or sleep disturbance rather than drowsiness; if this occurs, discontinue and consult your pharmacist or GP
- Allergic skin reactions in those sensitive to chlorphenamine or any excipient
- Blood disorders with very prolonged use — very rare at over-the-counter doses
Stop using and seek medical help if you experience:
- Paradoxical excitation in a child rather than expected drowsiness — discontinue and seek pharmacist or GP advice
- Significant urinary retention or inability to pass urine
- Signs of a serious allergic reaction including facial swelling, throat swelling, or difficulty breathing — call 999 immediately
- Any symptom that concerns you
Report any unexpected reaction via the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk or speak to your Pearl Chemist Group pharmacist.
How to Store Allerief Antihistamine Solution
- Temperature: Store below 25°C. Keep away from direct sunlight and heat sources.
- Do not refrigerate.
- Cap: Replace the cap firmly after every use to maintain hygiene and prevent contamination.
- Children: Keep out of the sight and reach of children at all times. Accidental ingestion of an antihistamine solution by a child can cause serious harm — store safely.
- Expiry: Do not use after the expiry date printed on the bottle and outer packaging.
- After opening: Check the product label for any post-opening discard guidance specific to this product.
- Disposal: Return unused or out-of-date medicine to your Pearl Chemist Group pharmacy for safe disposal.
Who Is Allerief Antihistamine Solution Suitable For?
Allerief Antihistamine Solution is suitable for adults and children aged 2 and over who experience the symptoms of allergic conditions and who require a liquid antihistamine preparation for ease of administration or accurate age-based dosing.
Suitable for:
- Adults experiencing symptoms of hayfever, allergic rhinitis, urticaria, or other allergic skin reactions
- Children aged 2 and over at age-appropriate doses under adult supervision
- Those who find tablet antihistamines difficult to swallow
- Situations where an overnight sedating antihistamine is acceptable or beneficial, such as treating nighttime allergy symptoms
- Short-term management of itching and rash from insect bites, food allergies, or drug reactions
Not suitable for:
- Children under 2 years without prior medical advice
- Anyone taking or who has taken an MAOI within the last 14 days — serious interaction
- Anyone with a known hypersensitivity to chlorphenamine or any ingredient including sodium benzoate
- Neonates or premature infants
- Use by anyone who needs to drive or operate machinery after administration
Use with caution or seek advice first if you:
- Have epilepsy or a history of seizures — chlorphenamine may lower the seizure threshold
- Have an enlarged prostate or urinary retention — chlorphenamine's anticholinergic effects can worsen this
- Have glaucoma — anticholinergic effects may raise intraocular pressure
- Have liver disease
- Take any other CNS depressant, sedative, or anticholinergic medicine
- Are pregnant or breastfeeding
- Are elderly — increased sensitivity to anticholinergic and sedating effects
- Have diabetes or are monitoring sugar intake — the solution contains sucrose
Our Pearl Chemist Group pharmacists can advise on appropriate antihistamine selection based on your individual circumstances and needs.
Active Ingredients in Allerief Antihistamine Solution
| Ingredient | Strength | Role |
|---|---|---|
| Chlorphenamine maleate | 2mg per 5ml | A first-generation H1 antihistamine that provides comprehensive symptomatic relief of allergic conditions by competitively blocking histamine receptors throughout the body. Chlorphenamine prevents histamine from binding to H1 receptors in the nasal mucosa, eyes, skin, and airways, relieving the sneezing, runny nose, itchy and watery eyes, urticaria, skin itching, and rash caused by allergic responses. As a first-generation antihistamine, it crosses the blood-brain barrier and produces a significant sedating effect in most users. This sedation can be helpful when managing allergic conditions that disrupt sleep, but requires users to avoid driving and operating machinery during treatment. Its relatively short duration of action compared with second-generation antihistamines means dosing every 4 to 6 hours is required for sustained relief. |
Allerief Antihistamine Solution Dosage — How Much to Take
Adults and young people aged 12 and over
- Dose: 10ml (4mg — equivalent to 2 x 5ml doses) every 4 to 6 hours as needed.
- Maximum daily dose: 6 doses (60ml / 24mg) in any 24-hour period.
Children aged 6 to 11 years
- Dose: 5ml (2mg) every 4 to 6 hours as needed.
- Maximum daily dose: 6 doses (30ml / 12mg) in any 24-hour period.
- Administer under adult supervision.
Children aged 2 to 5 years
- Dose: 2.5ml (1mg) every 4 to 6 hours as needed.
- Maximum daily dose: 6 doses (15ml / 6mg) in any 24-hour period.
- Administer under adult supervision.
Children under 2 years
Not recommended without prior medical advice.
Elderly patients
Use with caution. Elderly patients are more sensitive to the sedating and anticholinergic effects of chlorphenamine. Consider using half the adult dose initially and seek pharmacist or GP guidance before regular use.
Important dosage notes
- Measure doses accurately using the measuring device provided or a calibrated 5ml oral syringe. Do not use a household teaspoon.
- Do not exceed the stated maximum daily dose for any age group.
- Do not use alongside other antihistamine or sedating preparations without pharmacist guidance.
- Do not take within 14 days of stopping an MAOI medicine.
Precautions When Using Allerief Antihistamine Solution
Before use
- Confirm you are not taking an MAOI or have not done so in the last 14 days — this is a critical safety check.
- Check the expiry date on the bottle and that the seal is intact before first use.
- Review all drug interactions and consult your pharmacist if you take any regular medicines.
- Do not use in children under 2 without medical advice.
- Consider whether the sedating effect of this product is acceptable or beneficial for the time and situation of use.
During use
- Measure doses carefully using a calibrated 5ml spoon or oral syringe.
- Do not exceed the maximum number of doses for any age group in 24 hours.
- Do not allow anyone who has taken this medicine to drive or operate machinery.
- Avoid alcohol completely during treatment.
- Do not take alongside other antihistamines or CNS depressants without pharmacist guidance.
When to seek urgent medical advice
- If a child receives an excessive dose — contact NHS 111 or go to accident and emergency immediately.
- A severe allergic reaction occurs despite antihistamine treatment — call 999 immediately.
- You develop unusual or paradoxical excitation rather than sedation, particularly in young children — seek medical advice.
Our Pearl Chemist Group pharmacists are available for guidance on antihistamine selection and allergy management for all ages.
Full Ingredients in Allerief Antihistamine Solution
The active ingredient is chlorphenamine maleate 2mg per 5ml.
Excipients (inactive ingredients)
- Sucrose — sweetening agent providing palatability; those with diabetes or sucrose intolerance should be aware of its presence and take it into account when monitoring sugar intake
- Sodium benzoate (E211) — preservative preventing microbial growth in the solution after opening; those with known sensitivity to benzoate preservatives should consult their pharmacist before use
- Citric acid — acidulant that contributes to flavour balance and helps maintain pH stability of the solution
- Flavouring — improves the palatability of the solution, particularly for children
- Purified water — aqueous base of the solution
This product contains sucrose (relevant for those with diabetes or monitoring sugar intake) and sodium benzoate (E211) (relevant for those with benzoate sensitivity). If you have any concern about any ingredient, consult a Pearl Chemist Group pharmacist before use.
Last reviewed: May 2026.
Always read the patient information leaflet before use. A copy is included in the pack. For advice, speak to a Pearl Chemist pharmacist or call +44 (0)20 8672 2157.
What Is Allerief Antihistamine Solution Used For?
Allergic reactions can range from the mildly inconvenient to the significantly distressing, and having an effective antihistamine readily available is an important part of managing both everyday allergic conditions and unexpected allergic responses. Allerief Antihistamine Solution is a liquid antihistamine preparation containing chlorphenamine maleate at 2mg per 5ml, providing a versatile and easy-to-administer treatment for a wide range of allergic conditions across all appropriate age groups, from young children through to adults. The liquid format is particularly valuable for those who have difficulty swallowing tablets and for children, where accurate weight- and age-based dosing in a measured liquid form is more practical and reliable.
Chlorphenamine maleate is a first-generation antihistamine that works by competitively blocking histamine H1 receptors throughout the body, preventing histamine from binding and triggering the cascade of symptoms associated with allergic reactions. Allerief Antihistamine Solution is indicated for the symptomatic relief of allergic conditions including hayfever and seasonal allergic rhinitis, perennial allergic rhinitis, urticaria and allergic skin reactions, insect bites and stings, food allergy reactions causing itching and rash, and other drug reactions producing similar symptoms. It can be used to relieve sneezing, runny nose, nasal congestion, itchy and watery eyes, itchy skin, rash, and urticaria wheals associated with these conditions.
As a first-generation antihistamine, chlorphenamine crosses the blood-brain barrier more readily than second-generation antihistamines such as cetirizine or loratadine, and this results in a significant tendency to cause drowsiness in most users. This sedating property is sometimes useful — it can help children or adults who are experiencing disturbed sleep due to allergy symptoms to rest more comfortably overnight. However, it also means that Allerief Antihistamine Solution must not be used by anyone who needs to drive or operate machinery following administration, and alcohol must be avoided during treatment as it significantly magnifies the sedating effect.
Allerief Antihistamine Solution is suitable for adults and children from 2 years of age at age-appropriate doses. It must not be used in children under 2 without medical advice and must not be taken within 14 days of stopping an MAOI medicine. If you are managing a severe allergic reaction or anaphylaxis, seek emergency help immediately rather than relying on antihistamine treatment alone. For guidance on appropriate allergy management, speak to a Pearl Chemist Group pharmacist, or browse our full allergy treatment range.
How to Use Allerief Antihistamine Solution
- Shake the bottle if required. Check the label for instructions. Shake well before use if indicated to ensure even distribution of the active ingredient throughout the solution.
- Measure the correct dose accurately. Use the measuring device provided with the product or a calibrated 5ml oral syringe. Measure the correct volume for the age and weight of the person being treated. Do not use a household teaspoon, which may not hold exactly 5ml.
- Administer the measured dose. Give the measured dose by mouth. The solution may be swallowed directly or, for young children, measured into a small amount of water or squash if the child finds the taste difficult to accept. Do not mix with large volumes of liquid, as it is then difficult to ensure the full dose is consumed.
- Repeat as needed at the correct interval. A further dose may be given every 4 to 6 hours as needed, up to the stated maximum number of doses in 24 hours.
- Replace the cap securely after every use. Store the bottle as directed and keep out of reach of children.
Important reminders
- The sedating effect typically begins within 30 to 60 minutes of a dose. Do not allow the person taking the medicine to drive or operate machinery after administration.
- Avoid giving alcohol to anyone taking this solution.
- For children's doses, always measure carefully — the doses for 2 to 5 year olds (2.5ml) and 6 to 11 year olds (5ml) are quite small and must be measured precisely.
Allerief Antihistamine Solution Side Effects
Chlorphenamine maleate is a first-generation antihistamine with a well-known profile of sedating and anticholinergic side effects. These are more pronounced than with second-generation antihistamines such as cetirizine.
Common side effects (may affect more than 1 in 10 people)
- Drowsiness and sedation — this is the most common and expected effect; can range from mild to significant depending on the individual and the dose
- Dry mouth — due to anticholinergic activity
- Dizziness or light-headedness
Less common side effects (may affect between 1 in 10 and 1 in 100 people)
- Difficulty passing urine, particularly in men with an enlarged prostate
- Blurred vision
- Constipation
- Headache
- Nausea or stomach discomfort
- Palpitations or irregular heartbeat in some individuals
Rare side effects (may affect fewer than 1 in 100 people)
- Paradoxical excitation, particularly in children — manifesting as restlessness, agitation, hyperactivity, or sleep disturbance rather than drowsiness; if this occurs, discontinue and consult your pharmacist or GP
- Allergic skin reactions in those sensitive to chlorphenamine or any excipient
- Blood disorders with very prolonged use — very rare at over-the-counter doses
Stop using and seek medical help if you experience:
- Paradoxical excitation in a child rather than expected drowsiness — discontinue and seek pharmacist or GP advice
- Significant urinary retention or inability to pass urine
- Signs of a serious allergic reaction including facial swelling, throat swelling, or difficulty breathing — call 999 immediately
- Any symptom that concerns you
Report any unexpected reaction via the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk or speak to your Pearl Chemist Group pharmacist.
How to Store Allerief Antihistamine Solution
- Temperature: Store below 25°C. Keep away from direct sunlight and heat sources.
- Do not refrigerate.
- Cap: Replace the cap firmly after every use to maintain hygiene and prevent contamination.
- Children: Keep out of the sight and reach of children at all times. Accidental ingestion of an antihistamine solution by a child can cause serious harm — store safely.
- Expiry: Do not use after the expiry date printed on the bottle and outer packaging.
- After opening: Check the product label for any post-opening discard guidance specific to this product.
- Disposal: Return unused or out-of-date medicine to your Pearl Chemist Group pharmacy for safe disposal.
Who Is Allerief Antihistamine Solution Suitable For?
Allerief Antihistamine Solution is suitable for adults and children aged 2 and over who experience the symptoms of allergic conditions and who require a liquid antihistamine preparation for ease of administration or accurate age-based dosing.
Suitable for:
- Adults experiencing symptoms of hayfever, allergic rhinitis, urticaria, or other allergic skin reactions
- Children aged 2 and over at age-appropriate doses under adult supervision
- Those who find tablet antihistamines difficult to swallow
- Situations where an overnight sedating antihistamine is acceptable or beneficial, such as treating nighttime allergy symptoms
- Short-term management of itching and rash from insect bites, food allergies, or drug reactions
Not suitable for:
- Children under 2 years without prior medical advice
- Anyone taking or who has taken an MAOI within the last 14 days — serious interaction
- Anyone with a known hypersensitivity to chlorphenamine or any ingredient including sodium benzoate
- Neonates or premature infants
- Use by anyone who needs to drive or operate machinery after administration
Use with caution or seek advice first if you:
- Have epilepsy or a history of seizures — chlorphenamine may lower the seizure threshold
- Have an enlarged prostate or urinary retention — chlorphenamine's anticholinergic effects can worsen this
- Have glaucoma — anticholinergic effects may raise intraocular pressure
- Have liver disease
- Take any other CNS depressant, sedative, or anticholinergic medicine
- Are pregnant or breastfeeding
- Are elderly — increased sensitivity to anticholinergic and sedating effects
- Have diabetes or are monitoring sugar intake — the solution contains sucrose
Our Pearl Chemist Group pharmacists can advise on appropriate antihistamine selection based on your individual circumstances and needs.
Active Ingredients in Allerief Antihistamine Solution
| Ingredient | Strength | Role |
|---|---|---|
| Chlorphenamine maleate | 2mg per 5ml | A first-generation H1 antihistamine that provides comprehensive symptomatic relief of allergic conditions by competitively blocking histamine receptors throughout the body. Chlorphenamine prevents histamine from binding to H1 receptors in the nasal mucosa, eyes, skin, and airways, relieving the sneezing, runny nose, itchy and watery eyes, urticaria, skin itching, and rash caused by allergic responses. As a first-generation antihistamine, it crosses the blood-brain barrier and produces a significant sedating effect in most users. This sedation can be helpful when managing allergic conditions that disrupt sleep, but requires users to avoid driving and operating machinery during treatment. Its relatively short duration of action compared with second-generation antihistamines means dosing every 4 to 6 hours is required for sustained relief. |
Allerief Antihistamine Solution Dosage — How Much to Take
Adults and young people aged 12 and over
- Dose: 10ml (4mg — equivalent to 2 x 5ml doses) every 4 to 6 hours as needed.
- Maximum daily dose: 6 doses (60ml / 24mg) in any 24-hour period.
Children aged 6 to 11 years
- Dose: 5ml (2mg) every 4 to 6 hours as needed.
- Maximum daily dose: 6 doses (30ml / 12mg) in any 24-hour period.
- Administer under adult supervision.
Children aged 2 to 5 years
- Dose: 2.5ml (1mg) every 4 to 6 hours as needed.
- Maximum daily dose: 6 doses (15ml / 6mg) in any 24-hour period.
- Administer under adult supervision.
Children under 2 years
Not recommended without prior medical advice.
Elderly patients
Use with caution. Elderly patients are more sensitive to the sedating and anticholinergic effects of chlorphenamine. Consider using half the adult dose initially and seek pharmacist or GP guidance before regular use.
Important dosage notes
- Measure doses accurately using the measuring device provided or a calibrated 5ml oral syringe. Do not use a household teaspoon.
- Do not exceed the stated maximum daily dose for any age group.
- Do not use alongside other antihistamine or sedating preparations without pharmacist guidance.
- Do not take within 14 days of stopping an MAOI medicine.
Precautions When Using Allerief Antihistamine Solution
Before use
- Confirm you are not taking an MAOI or have not done so in the last 14 days — this is a critical safety check.
- Check the expiry date on the bottle and that the seal is intact before first use.
- Review all drug interactions and consult your pharmacist if you take any regular medicines.
- Do not use in children under 2 without medical advice.
- Consider whether the sedating effect of this product is acceptable or beneficial for the time and situation of use.
During use
- Measure doses carefully using a calibrated 5ml spoon or oral syringe.
- Do not exceed the maximum number of doses for any age group in 24 hours.
- Do not allow anyone who has taken this medicine to drive or operate machinery.
- Avoid alcohol completely during treatment.
- Do not take alongside other antihistamines or CNS depressants without pharmacist guidance.
When to seek urgent medical advice
- If a child receives an excessive dose — contact NHS 111 or go to accident and emergency immediately.
- A severe allergic reaction occurs despite antihistamine treatment — call 999 immediately.
- You develop unusual or paradoxical excitation rather than sedation, particularly in young children — seek medical advice.
Our Pearl Chemist Group pharmacists are available for guidance on antihistamine selection and allergy management for all ages.
Full Ingredients in Allerief Antihistamine Solution
The active ingredient is chlorphenamine maleate 2mg per 5ml.
Excipients (inactive ingredients)
- Sucrose — sweetening agent providing palatability; those with diabetes or sucrose intolerance should be aware of its presence and take it into account when monitoring sugar intake
- Sodium benzoate (E211) — preservative preventing microbial growth in the solution after opening; those with known sensitivity to benzoate preservatives should consult their pharmacist before use
- Citric acid — acidulant that contributes to flavour balance and helps maintain pH stability of the solution
- Flavouring — improves the palatability of the solution, particularly for children
- Purified water — aqueous base of the solution
This product contains sucrose (relevant for those with diabetes or monitoring sugar intake) and sodium benzoate (E211) (relevant for those with benzoate sensitivity). If you have any concern about any ingredient, consult a Pearl Chemist Group pharmacist before use.
Last reviewed: May 2026.
Always read the patient information leaflet before use. A copy is included in the pack. For advice, speak to a Pearl Chemist pharmacist or call +44 (0)20 8672 2157.
FAQs
Allerief Antihistamine Solution can help to relieve the symptoms of a broad range of allergic conditions. These include hayfever and seasonal allergic rhinitis (sneezing, runny nose, itchy and watery eyes), perennial allergic rhinitis caused by dust mites, pet dander, or mould, urticaria and allergic skin rashes, itching and rash from insect bites and stings, food allergy reactions causing itching or hives, and drug reactions producing similar symptoms. It is effective for the symptomatic management of these conditions but does not treat the underlying allergy.
Yes. Chlorphenamine is a first-generation antihistamine that causes significant drowsiness in most users. This is one of the most common and expected effects of the medicine. You must not drive or operate machinery after taking Allerief Antihistamine Solution. Alcohol significantly worsens the sedating effect and must be avoided entirely during treatment. If you need an antihistamine that is less likely to cause daytime drowsiness, speak to your Pearl Chemist Group pharmacist about second-generation alternatives such as cetirizine or loratadine.
The liquid solution format is particularly valuable in two main situations. First, for young children where accurate age-based dosing in small, measured volumes is safer and more practical than breaking tablets. Second, for adults or elderly individuals who have difficulty swallowing tablets. The solution also allows for easy dose adjustment across age groups from the same bottle, which is a practical advantage for family use.
The sedating effect of chlorphenamine can be useful when managing allergy symptoms that are significantly disrupting a child's sleep. An appropriate dose given in the evening can help the child to sleep more comfortably. However, it should not be used primarily or solely as a sleep aid — it should be used for its antihistamine properties in children who have genuine allergic symptoms. If you are considering using Allerief specifically to help a child sleep, speak to your pharmacist or GP first to confirm it is appropriate for the child's age, weight, and health status.
Both contain antihistamines and relieve hayfever symptoms, but there are meaningful differences. Chlorphenamine in Allerief is a first-generation antihistamine that causes significant sedation, requires dosing every 4 to 6 hours for ongoing coverage, and has broader anticholinergic effects. Cetirizine is a second-generation antihistamine that is substantially less sedating, requires only once-daily dosing, and is generally preferred for daytime hayfever management in adults. Allerief may be preferred in situations where its sedating effect is acceptable or beneficial, such as in children at night or in adults who do not need to drive. For most adults managing daytime hayfever, a once-daily second-generation antihistamine such as cetirizine is typically more convenient and better tolerated.
MAOIs interact with chlorphenamine in a way that can produce unpredictable and potentially dangerous effects, including enhanced sedation and anticholinergic toxicity. MAOIs remain active in the body for up to 14 days after the last dose, which is why a 14-day washout period is required before chlorphenamine can be used safely. If you take any medicine for depression, Parkinson's disease, or another condition and are unsure whether it has MAOI activity, always check with your pharmacist before taking any antihistamine solution.
For children aged 2 to 5, the dose is 2.5ml per administration. This is a small volume that must be measured precisely. Use a calibrated 5ml oral syringe or the measuring device supplied with the product rather than a household teaspoon, which is not an accurate measure and could lead to significant over or under-dosing. Draw up to exactly the 2.5ml mark on the syringe and administer directly into the child's mouth or into a small amount of water. If you are unsure how to measure the dose accurately, your Pearl Chemist Group pharmacist can show you how.